Application Value of Procalcitonin,C Reactive Protein and CD4+T Lymphocyte in Early Diagnosis of Mycobaterium Tuberculosis Infection in Patients with Human Immunodeficiency Virus
Objective:To investigate the application value of procalcitonin (PCT),C reactive protein (CRP) and CD4+T lymphocyte in early diagnosis of Mycobaterium tuberculosis (MT) infection in patients with human immunodeficiency virus (HIV) infection.Method:A total of 69 patients with HIV infection admitted to the Third People's Hospital of Changzhou from January 2021 to May 2024 were selected as the study objects.They were divided into simple HIV infection group (n=35) and HIV combined with TB infection group (n=34) according to whether they were infected with MT.The PCT,CRP and CD4+T lymphocyte levels of patients in the two groups were detected,and the differences of the above indexes between the two groups were compared,and the correlation analysis were conducted for the above indexes of patients with HIV combined with TB infection.The efficacy of PCT,CRP and CD4+T lymphocyte levels in the early diagnosis of MT were evaluated by receiver operating characteristic (ROC) curve.Result:The levels of PCT and CRP in HIV combined with TB infection group were significantly higher than those in simple HIV infection group,and the level of CD4+T lymphocytes was significantly lower than that in simple HIV infection group,the differences were statistically significant (P<0.05).In patients with HIV combined with TB infection,PCT and CRP levels were positively correlated (rs=0.607,P<0.001),and CD4+T lymphocyte levels were negatively correlated with PCT and CRP levels (rs=-0.751,-0.700,P<0.001).ROC curve analysis showed that the area under the curve (AUC) of PCT,CRP and CD4+T lymphocytes combined detection of MT infection was 0.911,and the specificity was 97.1％,which were significantly higher than those of single detection.Conclusion:The combined detection of PCT,CRP and CD4+T lymphocyte levels is of high value in the early diagnosis of MT infection in patients with HIV infection.
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