Effects of Different Super-ovulation Regimens on Endometrial Receptivity and Pregnancy Outcomes in Patients with Polycystic Ovary Syndrome
Objective:To investigate the effects of different super-ovulation regimens on endometrial receptivity and pregnancy outcomes in patients with polycystic ovary syndrome (PCOS).Method:A retrospective analysis was performed on 195 patients with PCOS admitted to the First Affiliated Hospital of Xiamen University from March 2021 to March 2024.According to different super-ovulation regimens,the patients were divided into group A (n=50,using antagonist regimens),group B (n=87,using luteal phase length regimens),and group C (n=58,using improved ultra-long regimens).Ovulation induction,endometrial receptivity,embryo status and pregnancy outcome were compared among the three groups.Result:The dosage and days of gonadotropin (Gn) in group B and group C were higher than those in group A (P<0.05).There were no significant differences in the levels of follicle-stimulating hormone (FSH),luteinizing hormone (LH) and estradiol (E2) among the three groups on trigger day (P>0.05).After treatment,the endometrial thickness,endometrial volume,and endometrial blood flow of the three groups were higher than those before treatment,and the indexes of group B and group C were higher than those of group A (P<0.05).However,after treatment,there were no statistical significance in indexes between group B and group C (P>0.05).There were no significant differences in the total number of eggs obtained,the number of transferable embryos,the number of high-quality embryos,the clinical pregnancy rate and the early abortion rate among the three groups (P>0.05).Conclusion:Different superovulation regimens can improve ovum quality and achieve better pregnancy outcome in PCOS patients.Among them,luteal phase long regimen and modified ultra-long regimen have more advantages in improving endometrial receptibility,while antagonist regimen can reduce the dosage and time of Gn.
万方数据
维普
