Expression and Significance of ASAP1 and P53 in High-grade Serous Ovarian Carcinoma
Objective:To investigate the expression and clinicopathological significance of adenosine diphosphate ribosylation factor guanylate kinase 1 (ASAP1) and P53 in high-grade serous ovarian carcinoma (HGSOC).Method:A total of 108 cases of ovarian serous tumor tissue wax samples from May 2020 to May 2024 in Jiangxi Maternal and Child Health Hospital were collected and divided into four groups according to pathological types,including 40 cases of HGSOC as group A,28 cases of low-grade ovarian serous cancer as group B,20 cases of borderline ovarian serous tumor as group C,and 20 cases of ovarian serous cystadenoma as group D.The expression of ASAP1 and P53 in all groups was detected by immunohistochemical Elivision two-step method,and the expression differences of ASAP1 and P53 in different groups were compared.The relationship between the expression of ASAP1,P53 in group A and clinical FIGO stage,lymph node metastasis and other clinicopathological features was analyzed.Result:(1) The positive rates of ASAP1 and P53 in group A were significantly higher than those in group B,group C,and group D,the differences were statistically significant (P<0.05),the positive rate of ASAP1 in group B was significantly higher than that in group C and group D,the differences were statistically significant (P<0.05).(2) The positive rate of ASAP1 in patients with lymph node metastasis in group A was significantly higher than that in patients without lymph node metastasis,the difference was statistically significant (P<0.05).The positive rate of ASAP1 in patients with FIGO stage Ⅲ,Ⅳ was significantly higher than that in patients with FIGO stage Ⅰ,Ⅱ,the difference was statistically significant (P<0.05).(3) There is a positive correlation between ASAP1 and P53 expression in group A (P<0.01).Conclusion:ASAP1 and P53 play a synergistic role in the occurrence and development of HGSOC,the expression of ASAP1 is related to FIGO staging and lymph node metastasis of HGSOC,suggesting that ASAP1 may be a potential indicator for predicting the biological behavior and prognosis of HGSOC.
万方数据
维普
