中国医学创新2025，Vol.22Issue(23) ：10-14.DOI:10.3969/j.issn.1674-4985.2025.23.003

盐酸硫必利片联合芍麻止痉颗粒对儿童抽动障碍的影响

The Impact of Tiapride Hydrochloride Tablets Combined with Shaoma Zhijing Granules on Children with Tic Disorders

梁慧 刘宇亮 杨小鑫
中国医学创新2025，Vol.22Issue(23) ：10-14.DOI:10.3969/j.issn.1674-4985.2025.23.003
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盐酸硫必利片联合芍麻止痉颗粒对儿童抽动障碍的影响

The Impact of Tiapride Hydrochloride Tablets Combined with Shaoma Zhijing Granules on Children with Tic Disorders

梁慧 1刘宇亮 1杨小鑫1
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作者信息

  • 1. 瑞金市人民医院儿童保健科 江西 瑞金 342500
  • 折叠

摘要

目的:评估盐酸硫必利片联合芍麻止痉颗粒治疗儿童抽动障碍的临床效果.方法:本研究采用前瞻性、随机对照试验设计,于 2022 年 2 月—2024 年 7 月在瑞金市人民医院进行,共纳入儿童抽动障碍 102 例.按 1∶1 比例随机分为对照组(51 例)和试验组(51 例),对照组接受盐酸硫必利片治疗,试验组接受盐酸硫必利片与芍麻止痉颗粒联合治疗,对比两组抽动症状改善状况[耶鲁综合抽动严重程度量表(YGTSS)评分]、中医证候积分、行为和智力状况[Achenbach儿童行为量表(CBCL)评分、韦氏儿童智力量表评分]、神经递质[多巴胺(DA)、去甲肾上腺素(NE)、脑源性神经营养因子(BDNF)]水平、不良反应(食欲不振、头晕乏力、嗜睡、皮疹、腹泻).结果:治疗后,试验组YGTSS评分、中医证候积分低于对照组(P<0.05);试验组CBCL评分低于对照组,韦氏儿童智力评分高于对照组(P<0.05);试验组DA、NE水平低于对照组,BDNF水平高于对照组(P<0.05);试验组不良反应总发生率低于对照组(P<0.05).结论:盐酸硫必利片与芍麻止痉颗粒的联合使用治疗儿童抽动障碍,可改善抽动症状、行为和智力表现,优化神经递质水平,并减少不良反应,是一种安全且有效的治疗选择.

Abstract

Objective:To evaluate the clinical efficacy of Tiapride Hydrochloride Tablets combined with Shaoma Zhijing Granules in treating children with tic disorders.Method:This prospective,randomized controlled trial was conducted at People's Hospital of Ruijin City from February 2022 to July 2024,involving 102 children with tic disorders.Participants were randomly divided into control group(51 cases)and an experimental group(51 cases)at a 1:1 ratio.The control group received Tiapride Hydrochloride Tablets treatment,while the experimental group received a combination of Tiapride Hydrochloride Tablets and Shaoma Zhijing Granules.Tic symptoms[Yale global tic severity scale(YGTSS)score],traditional Chinese medicine syndrome scores,behavior and intelligence[Achenbach child behavior checklist(CBCL)score and Wechsler intelligence scale for children score],the levels of neurotransmitter[dopamine(DA),norepinephrine(NE),and brain-derived neurotrophic factor(BDNF)],and adverse reactions(loss of appetite,dizziness and fatigue,drowsiness,rash,diarrhea)were compared between the two groups.Result:After treatment,the experimental group showed lower YGTSS scores and traditional Chinese medicine syndrome scores than the control group(P<0.05).The experimental group also had lower CBCL score and higher Wechsler intelligence scale scores than the control group(P<0.05).The levels of DA and NE were lower,while BDNF levels were higher in the experimental group compared to the control group(P<0.05).The total rate of adverse reactions in the experimental group was lower than that in the control group(P<0.05).Conclusion:The combined use of Tiapride Hydrochloride Tablets and Shaoma Zhijing Granules in treating children with tic disorders is effective in improving tic symptoms,behavior and intelligence performance,and optimizing neurotransmitter levels,while reducing adverse reactions,it is a safe and effective treatment option.

关键词

盐酸硫必利片/芍麻止痉颗粒/儿童抽动障碍/神经递质水平

Key words

Tiapride Hydrochloride Tablets/Shaoma Zhijing Granules/Children with tic disorders/Neurotransmitter levels

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出版年

2025
中国医学创新
中国保健协会

中国医学创新

影响因子：1.706
ISSN：1674-4985
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