Changes of serum CD105 level in CIN grade Ⅲ patients with HR-HPV infection and clinical significance
[Objective]To investigate the changes and clinical significance of serum endoglin(CD 105)level in cervical intraepithelial neoplasia(CIN)grade Ⅲ patients with high-risk human papillomavirus(HR-HPV)infection.[Methods]A total of 352 CIN Ⅲ patients who underwent loop electrosurgical excision procedure(LEEP)in Henan Veterans Hospital from January 2018 to February 2022 were selected as the disease group,and 352 healthy women who underwent physical examination in the hospital during the same period were selected as the control group.The serum CD 105 levels were measured and compared between the two groups.According to the HPV infection of patients in the disease group,they were divided into HR-HPV infection group and non-HR-HPV infection group.The serum CD 105 levels between HR-HPV infection group and non-HR-HPV infection group were compared.The CIN Ⅲ patients were followed up for 1 year after surgery.During the follow-up period,the CIN Ⅲ patients with HR-HPV infection were divided into recurrence group and non-recurrence group according to the recurrence.The serum CD 105 levels and general information were compared between the recurrence group and the non-recurrence group.The influencing factors of postoperative recurrence in CIN Ⅲ patients with HR-HPV infection was analyzed by using multivariate logistic regression analysis,and the predictive value of serum CD 105 level for postoperative recurrence in CIN Ⅲ patients with HR-HPV infection was analyzed by drawing receiver operating characteristic(ROC)curve.[Results]The preoperative serum CD 105 level in the disease group was higher than that in the control group(P＜0.05).The preoperative serum CD105 level in the HR-HPV infection group was higher than that in the non-HR-HPV infection group(P＜0.05).A total of 24 cases were lost in the disease group,and 35 cases had postoperative recurrence among the 328 CIN Ⅲ patients,and the postoperative recurrence rate was 10.67％.Among the 289 CIN Ⅲ patients with HR-HPV infection,32 cases had postoperative recurrence,and the postoperative recurrence rate was 11.07％.The proportions of multiple sexual partners,menopause,high preoperative HR-HPV load,positive surgical margin,involved glands and serum CD 105 level before surgery,serum CD 105 level 6 months after surgery in the recurrence group were higher than those in the non-recurrence group(P＜0.05).Multivariate logistic regression analysis showed that menopause,high preoperative HR-HPV load,positive surgical margin,involvement of glands and high serum CD 105 levels before and 6 months after surgery were risk factors for postoperative recurrence in CIN Ⅲ patients with HR-HPV infection(P＜0.05).The ROC results showed that the sensitivity,specificity and area under curve(AUC)of serum CD 105 level 6 months after surgery in predicting postoperative recurrence of CIN Ⅲ patients with HR-HPV infection were 87.50％,72.76％and 0.841 respectively.The sensitivity,specificity and AUC of preoperative serum CD 105 level in predicting postoperative recurrence of CIN Ⅲ patients with HR-HPV infection were 81.25％,71.98％and 0.808 respectively.[Conclusion]The serum CD 105 level in CIN Ⅲ patients with HR-HPV infection is abnormally elevated,and the serum CD 105 level is a influencing factor for postoperative recurrence in such patients,and it has a good predictive value for postoperative recurrence and can be used as an important biochemical indicator for predicting the prognosis of CIN Ⅲ patients with HR-HPV infection.
cervical intraepithelial neoplasia grade Ⅲhigh-risk human papillomavirusendoglinprognosis
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