Organoid chip is a technology that uses advanced microfluidic technology to simulate the state of the human circulatory system to culture living cells.This technology can better reproduce the physiological and pathological processes in the human body,and provide reliable and reproducible preclinical models for growth and development of disease or drug screening.It can also effectively make up for the issue that traditional 2D cell,animal and organoid models cannot well reproduce the physiological and pathological processes in the human body and predict the poor therapeutic ability of drugs.The living cells in the organoid chip can be derived from human pluripotent stem cells,healthy people or patient stem cells,etc.This article focuses on the development of organoids and organoids chips,the classification of organoids chip materials and existing new technologies,the problems encountered in organoids chip cell culture and the application of organoids chips in clinical medicine.As an emerging fusion technology,organoids chip has unlimited application prospects,but it also faces many challenges,such as technical and material problems.
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