Effects of remazolam on hemodynamics and immediate postoperative cognitive function during general anesthesia induction in heart valve replacement surgery
[Objective]To observe the effect of remazolam on hemodynamics during induction of general anesthesia and immediate postoperative cognitive function in patients undergoing heart valve replacement surgery.[Methods]This is a prospective cohort study.The patients were included from June 2020 to May 2023.The study subjects were 98 patients with heart valve replacement.The enrolled patients were divided into the observation group(49 cases)and the control group(49 cases)by using the random number table.The control group was given routine general anesthesia.The observation group was given ramazolam assisted general anesthesia.The hemodynamic changes,depth of anesthesia and sedation,immediate postoperative cognitive function,and occurrence of anesthesia related side effects of the patients in the two groups were compared during the induction of general anesthesia.[Results]There was no statistically significant difference in heart rate(HR)and mean arterial pressure(MAP)between the two groups of patients before administration(T0),immediately after administration(T1),and after induction for 5 minutes(T2)(P＞0.05).At the instant of tracheal intubation(T3),HR and MAP of the observation group were 79.25± 10.17 times/min and 115.74±20.61 mmHg,respectively,which were lower than those of the control group(85.75±10.24 times/min and 130.41±20.77 mmHg).At 5 minutes after intubation(T4),the HR and MAP of the observation group were 78.62±10.61 times/min and 108.44±20.25 mmHg,respectively;compared with the control group(84.27±10.32 times/min and 120.25±20.27 mmHg),the above indicators were lower(P＜0.05).Under different anesthesia schemes,the time of bilateral bispectral index(BIS)≤60 after induction in the observation group was 60.25±10.36 s,and the BIS value before tracheal intubation was 58.24±10.61;compared with the control group(67.25±10.41 s,65.77±10.46),the above indicators were lower(P＜0.05).Under different anesthesia regimens,the Mini-Mental State Examination(MMSE)score and Montreal Cognitive Assessment(MoCA)score of the observation group immediately after surgery were 26.62±5.13 and 25.45±5.17,respectively;compared with the control group 23.11±5.46 and 22.16± 5.24,the above scores were higher(P＜0.05).Under different anesthesia regimens,the incidence of anesthesia related adverse reactions in the observation group was 12.24％(6/49),which was similar to 10.20％(5/49)in the control group(P＞0.05).[Conclusion]Remazolam assisted general anesthesia can effectively maintain hemodynamic stability during induction in patients undergoing heart valve replacement surgery,and has a positive significance in helping patients achieve satisfactory anesthesia depth faster and reducing immediate postoperative cognitive impairment.The combined use of this drug does not significantly increase the risk of adverse reactions and has high safety.
heart valve replacement surgerygeneral anesthesiaremazolamhemodynamicscognitive function
万方数据
维普
