Bioinformatics analysis of the effect of triggering receptor expresses on myeloid cells-2 on low-grade glioma
[Objective]To explore the expression of triggering receptor expresses on myeloid cells-2(TREM-2)in low-grade glioma(LGG)and its impact on patient survival by bioinformatics,and to provide potential targets for the early detection,early diagnosis and treatment of LGG.[Methods]The online websites GEPIA2 and UALCAN were used to analyze the expression difference of TREM-2 in LGG tumor tissue and normal tissue,the relationship with clinicopathological characteristics such as age,gender,race,tumor grade,and the effects of abnormal expression of TREM-2 in LGG tumor tissue on the overall survival rate in LGG patients.KEGG pathway enrichment analysis of TREM-2-related genes was conducted by DAVID 6.8 software.The correlation between TREM-2 expression and tumor purity and degree of immune cell infiltration was analyzed using the TIMER database.[Results]Compared with normal tissues,the expression of TREM-2 in LGG tumor tissues was significantly higher than that in the normal group(P＜0.5),and it was correlated with tumor grade and histological type(P＜0.001)and not correlated with the patient's age,gender and race(P＞0.05).Survival analysis showed that TREM-2 was closely related to the prognosis of LGG.The higher the expression of LGG,the lower the overall survival rate of patients(P=0.00025 and P=0.0029),and disease free survival rate also decreased(P=0.015).Pathway enrichment results showed that the gene pathways positively related to TREM-2 mainly involved tuberculosis,cancer pathway,phagosome,etc.,and the negatively related gene pathways mainly involved MAPK signaling pathway,neuroactive ligand-receptor.The expression of TREM-2 was positively correlated with the infiltration level of 6 kinds of immune cells in the tumor microenvironment.[Conclusion]The expression of TREM-2 in LGG tumor tissues is significantly increased,and is related to the survival rate of patients.It is a potential target for the diagnosis and treatment of LGG.
low-grade gliomatriggering receptor expresses on myeloid cells-2TCGAexpression differenceoverall survival rate
万方数据
维普
