Diagnostic value of routine blood parameters in children with infectious mononucleosis
[Objective]To study the diagnostic value of routine blood parameters in the diagnosis of infectious mononucleosis(IM)in children.[Methods]Sixty patients with childhood infectious mononucleosis(IM)initially diagnosed in Luoyang Maternal and Child Health Hospital from June 2021 to October 2022 were retrospectively collected as the study group,and 40 healthy children who were examined in the hospital during the same period were selected as the control group.The patients'general data and laboratory tests were analyzed to compare the differences between the two groups,and to analyze the expression differences in white blood cells(WBC),neutrophil/lymphocyte ratio(NLR),monocyte/lymphocyte ratio(MLR),and lymphocyte community parameters[lymphocyte complexity(L-X),lymphocyte fluorescence intensity(L-Y),lymphocyte size(L-Z)]between the two groups.The study group was divided into group A(IM group)and group B(cytomegalovirus and other infections group)according to whether the diagnosis of IM in children was confirmed,and the differences in NLR,MLR,L-X,L-Y,and L-Z between group A and group B were compared.Diagnostic and predictive value of NLR,MLR,and lymphocyte community parameters L-Y and L-Z for IM patients was analyzed using receiver operating characteristic(ROC)curve.[Results]WBC of the study group were significantly higher than those of the control group,and NLR and MLR were significantly lower than those of the control group(P＜0.05).Lymphocyte colony parameters L-Y and L-Z of the study group were significantly higher than those of the control group(P＜0.05),and the difference in lymphocyte colony parameter L-X between the study group and the control group was not significant(P＞0.05).L-Y and L-Z in group A were significantly higher than those in group B(P＜0.05),NLR and MLR were significantly lower than those in group B(P＜0.05),and the differences in CRP,heterogeneous lymphocyte ratio and L-X were not significant between the two groups(P＞0.05).The sensitivity of NLR,MLR and lymphocyte community parameters L-Y and L-Z in predicting IM was 0.806,0.889,0.694 and 0.750,respectively,and the specificity was 0.828,0.703,0.937 and 0.891,the area under the curve was 0.889,0.868,0.862 and 0.877,respectively,and the optimal cut-off values were 0.485,0.095,803.1 and 961.85,respectively.[Conclusion]The blood cell parameters NLR and MLR and the lymphocyte colony parameters L-Y and L-Z express the immune function status of the body as well as quantify the internal structural changes of the cells respectively,which are more sensitive to reflect the changes of IM disease in children and can optimize the clinical diagnostic protocol of IM in children.
万方数据
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