Ameliorative effect of luteolin on D-galactose induced cognitive impairment in mice
[Objective]To investigate the effect and possible mechanism of luteolin on D-galactose induced cognitive impairment in mice.[Methods]Mice were randomly divided into normal group,model group and luteolin group,with 10 mice in each group.Hippocampal cognitive behaviors and expressions of related proteins were detected by water maze detection and immunofluorescence.[Results]There was no significant difference in activity between the groups.In the model group,the old and new food recognition index was significantly decreased,the latency of finding the platform was prolonged,the residence time in the target quadrant was shortened,the number of mature neurons in the hippocampus was decreased,and the expression of synaptic related proteins was decreased.The old and new food recognition index of mice in luteolin group was significantly increased,the latency of finding the platform was shortened,the residence time of mice in the target quadrant was prolonged,the number of mature neurons in hippocampus was increased,and the expression of synaptic related proteins was up-regulated.[Conclusion]Luteolin may improve D-galactose induced cognitive impairment in mice by enhancing oxygen free radical scavenging ability,protecting hippocampal neurons and enhancing synaptic plasticity.
万方数据
维普
