Diagnostic value of dual-phase18F-FDG PET/CT metabolic parameters in staging of colorectal cancer
[Objective]To investigate the correlation between metabolic parameters of dual-phase 18F-FDG PET/CT and clinicopathological characteristics of patients with colorectal cancer and the predictive value of metabolic parameters for T4 stage,lymph node metastasis and M stage.[Methods]According to the inclusion and exclusion criteria,46 patients with colorectal cancer who were pathologically confirmed and who underwent PET/CT examination before treatment were retrospectively analyzed.The metabolic parameters were measured and the clinicopathological data were collected.The ROC curves of MTV,MTV2.5(SUVmax=2.5 as threshold delineation of ROI statistically analysis),TLG and TLG2.5 on lymph node metastasis were analyzed.The optimal metabolic parameters were selected,and the correlation between metabolic parameters and pathological features was analyzed.The ROC curve was used to predict the diagnostic value of metabolic parameters for T4 stage,lymph node metastasis and M stage.[Results]The AUC value of MTV and TLG for lymph node metastasis was greater than MTV2.5,TLG2.5(0.752 vs.0.737,0.802 vs.0.787).The SUVmax,SUVpeak and SUL were positively correlated with T stage,lymph node metastasis and tumor length(r=0.335,0.409,0.297;0.319,0.376,0.297;0.299,0.401,0.332,P all＜0.05).The correlation coefficient between SUL and tumor length was higher than that between SUVmax.The MTV and TLG were positively correlated with T4 stage,lymph node metastasis and M stage(r=0.584,0.436,0.349;0.598,0.521,0.366,P all＜0.05),and TLG had the highest correlation coefficient.The SUVmax,SUVpeak and TLR were negatively correlated with tumor differentiation(r=-0.395,-0.298,-0.328,P all＜0.05).The TLG had a high predictive value for T4 stage,lymph node metastasis and M stage,with AUC values of 0.688,0.802 and 0.716,respectively.[Conclusion]MTV and TLG are more significant for lymph node metastasis than MTV2.5 and TLG2.5.Dual-phase PET/CT metabolic parameters are correlated with clinicopathological features,and TLG has an important significance for clinical staging.
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