Effect of spinal electrical stimulation on left stellate ganglion in experimental dogs with atrial fibrillation
[Objective]To investigate the effect of low-intensity spinal electrical stimulation(SCS)on the left stellate ganglion(LSG)function in experimental dogs with atrial fibrillation.[Methods]Twenty healthy adult beagle dogs underwent rapid atrial pacing(RAP)at the left atrial appendage to induce acute remodeling and establish an atrial fibrillation model,then they were randomly divided into two groups.Ten dogs in the experimental group were subjected to high-frequency electrical stimulation of the T1-2 spinal cord nerve using the minimum voltage intensity that caused muscle tremors as the stimulation threshold,and SCS was performed at 90％threshold intensity for 6 hours.Ten dogs in the control group were also subjected to low-intensity stimulation on the surface skin near Tl-2 for 6 hours.Heart rate changes induced by increasing voltage stimulation with LSG were determined in the basal state and at the end of 6 hours.The heart rate-voltage response curve for LSG was plotted against the percentage of stimulation voltage change in heart rate as abscissa and ordinate,respectively.[Results]The heart rate-voltage response curve of the control LSG did not change significantly;the heart rate-voltage response curve of the experimental LSG gradually became sluggish,and the percentage of the heart rate reduction caused by the same voltage decreased.[Conclusion]Low-intensity spinal electrical stimulation can inhibit the function of LSG in experimental dogs with atrial fibrillation.
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