Expression of serum miR-206 in patients with PCOS and its relationship with the endocrine of hypothalamus-pituitary-gonad axis
[Objective]To investigate the expression of serum microribonucleic acid-206(miR-206)in patients with polycystic ovary syndrome(PCOS)and its relationship with hypothalamus-pituitary-gonad axis endocrine.[Methods]Totally 148 PCOS patients admitted to our hospital from March 2020 to December 2022 were selected as the study group,and 133 healthy non-pregnant women with normal menstruation were selected as the control group at the same time.Real-time fluorescence quantitative polymerase chain reaction(qRT-PCR)was used to detect the expression of miR-206 in serum of all subjects,and the serum levels of follicle-stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),testosterone(T),prolactin(PRL)and progesterone(P)were detected by chemiluminescence immunoassay.The relationships between serum miR-206 expression and FSH,LH,E2,T,PRL,P in patients with PCOS were analyzed by Pearson correlation coefficient.[Results]The expression of serum miR-206 in the study group(0.38±0.07)was significantly lower than that in the control group(0.95±0.12)(P＜0.05).The serum FSH and P levels in the study group(5.12±1.19 mIU/mL,1.52±0.44 nmol/L)were significantly lower than those in the control group(6.58±1.34 mIU/mL,2.49±0.62 nmol/L),and the levels of serum LH,E2,T and PRL(10.96±2.24 mIU/mL,78.63±22.49 pg/mL,0.88+0.23 ng/mL,21.46±5.32 ng/mL)were significantly higher than those in the control group(6.73±1.85 mIU/mL,49.41±10.65 pg/mL,0.51± 0.12 ng/mL,16.35±3.21 ng/mL),and the differences were statistically significant(P＜0.05).Pearson correlation coefficient analysis showed that the expression of serum miR-206 of PCOS patients was negatively correlated with the levels of LH,E2,T and PRL(r=-0.546,-0.501,-0.533,-0.485,P＜0.05),but it was positively correlated with the levels of FSH and P(r=0.493,0.528,P＜0.05).[Conclusion]The expression of serum miR-206 of patients with PCOS is significantly decreased,and there is a certain correlation between it and the endocrine related indexes of hypothalamus-pituitary-gonad axis.
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