Relationship between long non-coding RNA expression and vascular endothelial function in lung adenocarcinoma and its influence on disease progress
[Objective]To observe the relationship between long non-coding RNA(lncRNA)and vascular endothelial function of adenocarcinoma of the lung and its influence on disease progression.[Methods]This is a retrospective study.The case was included from May 2020 to October 2022.The study object was 123 patients with adenocarcinoma of the lung.The expression of metastasis associated lung adenocarcinoma transcript 1(MALAT1)in tumor tissue of enrolled patients was detected by quantitative real-time PCR(qPCR).According to the reciever operating characteristic(ROC)curve analysis results,60 patients with.low expression of MALAT1 were classified as Group A,and 63 patients with high expression of MALAT1 were classified as Group B.The general data and clinical data of the patients in the two groups were collected and compared.Logistic multi-factor regression analysis summarized the main factors affecting the expression of MALAT1.Spearman correlation coefficient was used to verify the correlation between the expression of MALAT1 and vascular endothelial function and disease progression in patients with lung adenocarcinoma.[Results]The results of statistical univariate analysis showed that there were certain differences in general information such as age,maximum tumor diameter,number of tumors,as well as clinical data such as tumor differentiation,tumor infiltration depth,regional lymph node involvement,distant metastasis,and vascular endothelial function between the two groups of patients(P＜0.05).Logistic regression analysis showed that the main factors affecting the expression of MALAT1 in adenocarcinoma of the lung were the maximum tumor diameter＞5 cm,multiple tumors,poor differentiation,tumor invasion T3-T4,regional lymph node involvement N1-N2,distant metastasis Ml,vascular endothelial growth factor(VEGF)≥142 pg/mL,platelet-derived growth factor B(PDGF-B)≥200 pg/mL.After Spearman correlation coefficient test,the expression of MALAT1 was negatively correlated with the degree of tumor differentiation,but positively correlated with tumor infiltration depth,lymph node involvement,distant metastasis,VEGF expression,and PDGF-B.[Conclusion]The expression level of MALAT1 will continue to rise with the progression of lung adenocarcinoma patients and the worsening of vascular endothelial function.Knocking down the expression of MALAT1 can effectively improve the function of vascular endothelial cells and inhibit the deterioration of disease.MALAT1 is expected to become a new target for adenocarcinoma of the lung.
adenocarcinoma of the lunglong non-coding RNAmetastasis associated lung adenocarcinoma transcript 1progress of the conditionvascular endothelial function
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