Value of contrast-enhanced ultrasonography combined with serum P53 antibody in distinguishing differentiation degree of hepatocellular carcinoma
[Objective]To explore the differential value of contrast-enhanced ultrasonography combined with serum P53 antibody in the degree of differentiation of hepatocellular carcinoma.[Methods]The clinical data of 185 patients with hepatocellular carcinoma diagnosed through pathological examination admitted to our hospital from March 2020 to March 2023 were retrospectively analyzed,and they all underwent contrast-enhanced ultrasonography examination and serum P53 antibody testing after admission.According to the pathological differentiation degree of hepatocellular carcinoma,the patients were divided into high differentiation group(n=48),moderate differentiation group(n=82)and low differentiation group(n=55).The contrast-enhanced ultrasonography parameters(beginning enhancement time,peak time,peak intensity,enhancement duration,starting clearance time)in patients with different degrees of differentiation and serum P53 antibody level were compared.The differential value of contrast-enhanced ultrasonography and serum P53 antibody alone or in combination for the differentiation degree of hepatocellular carcinoma were analyzed.[Results]There was no statistically significant difference in the beginning enhancement time and peak intensity of contrast-enhanced ultrasonography in patients with high differentiation,moderate differentiation,and low differentiation hepatocellular carcinoma(P＞0.05).The peak time,enhancement duration,and starting clearance time of contrast-enhanced ultrasonography gradually decreased in high differentiation,moderate differentiation and low differentiation patients(P＜0.05),but the serum P53 antibody level gradually increased in high differentiation,moderate differentiation and low differentiation patients(P＜0.05).The sensitivity of peak time,enhancement duration and starting clearance time of contrast-enhanced ultrasonography alone and in combination for distinguishing low differentiation and medium to high differentiation of hepatocellular carcinoma were 65.45％,67.27％,69.09％and 85.45％respectively,and the specificity were 89.23％,87.69％,86.15％and 82.31％respectively,and the area under the curve(AUC)were 0.771,0.772,0.781 and 0.833 respectively.The sensitivity,specificity and AUC of serum P53 antibody level in distinguishing low differentiation and medium to high differentiation of hepatocellular carcinoma were 83.64％,83.08％and 0.836 respectively.The sensitivity,specificity and AUC of contrast-enhanced ultrasonography combined with serum P53 antibody in distinguishing low differentiation and medium to high differentiation of hepatocellular carcinoma were 96.36％,81.54％and 0.930 respectively,and the sensitivity and AUC of two joint identifications were higher than those of individual identifications(P＜0.05).[Conclusion]Both contrast-enhanced ultrasonography and serum P53 antibody can indicate the degree of differentiation of hepatocellular carcinoma,but the combination of the two has better value in differentiation.
hepatocellular carcinomacontrast-enhanced ultrasonographyP53 antibodydegree of differentiation
万方数据
维普
