Application of serum sCD68,AMH,HSP70 detection in diagnosis and prognosis of polycystic ovary syndrome
[Objective]To investigate the diagnostic efficacy of serum soluble CD68(sCD68),anti-Mulleran-tube hormone(AMH)and heat shock protein 70(HSP70)levels in polycystic ovary syndrome(PCOS)and their application value in prognosis.[Methods]A total of 230 patients with PCOS in Nanyang First People's Hospital from June 2021 to April 2023 were selected as the study objects,and were divided into mild group,moderate group and severe group according to menstruation,and 70 healthy subjects were selected as the control group.The serum levels of sCD68,AMH and HSP70 were compared before treatment.ROC analysis of the diagnostic value of serum indexes combined detection before treatment for PCOS.The serum levels and clinical data of patients with different prognosis were compared before treatment and 4 weeks after treatment.Logistic regression analysis was performed to analyze the risk factors of poor prognosis in PCOS patients.The risk of poor prognosis of patients with different levels of serum indexes was analyzed.[Results]Before treatment,the levels of serum sCD68,AMH and HSP70 in 4 groups were compared:severe group＞moderate group＞mild group＞control group(P＜0.05).The AUC of serum sCD68,AMH and HSP70 for diagnosis of PCOS before treatment was 0.736.Before treatment follicle number and ovarian volume in patients with good prognosis were lower than those with poor prognosis,sCD68,AMH and HSP70 levels in patients with poor prognosis were higher than those in patients with good prognosis before and 4 weeks after treatment(P＜0.05).Logistic regression analysis showed that follicle number,ovarian volume and serum sCD68,AMH and HSP70 were the risk factors for poor prognosis in PCOS patients(P＜0.05).The poor prognosis of patients with high levels of serum sCD68,AMH and HSP70 before and after 4 weeks of treatment was several times higher than those with low levels(P＜0.05).[Conclusion]Serum sCD68,AMH,HSP70 levels have important application value in clinical diagnosis of PCOS,and can be used as an effective serum factor to predict the outcome.
万方数据
维普
