Bioinformatics analysis of the relationship between CPEB4 expression and clinical pathological characteristics and prognosis of tumors
[Objective]To investigate whether CPEB4 gene is a tumor marker in tumors and to evaluate the relationship between prognosis,clinical correlation analysis and tumor microenvironment of CPEB4 in pan-carcinoma.[Methods]Online search of CPEB4 related literature on human tumor expression in PubMed,CNKI,Weipu and Wanfang databases,include and summarize the expression in related tumor cells,extract corresponding clinical data from the literature that meets the standards and conduct meta-analysis.Extract the sample information in the TCGA(Cancer Genome Atlas)database for pan-carcinogenic analysis and expand the relationship between clinical correlation research,prognosis degree and immunity of CPEB4 high and low expression groups in different tumor patients.[Results]The results of meta-analysis showed that CPEB4 was a poor prognostic factor in patients with advanced renal clear cell carcinoma,non-small cell lung cancer,glioma,colorectal adenocarcinoma and gastric adenocarcinoma.The results of pan-cancer differential analysis showed that CPEB4 was a polarizing factor in tumors,and the relationship between CPEB4 expression and tumor mutation burden(TMB),microsatellite instability(MSI),immune cell correlation and other immune-related genes in pan-carcinoma,and GSEA pathway enrichment analysis were carried out,and the results of meta-analysis were verified and expanded.[Conclusion]As a paradoxical factor in pan-carcinoma,CPEB4 can be an important reference factor for the detection index and prognosis of some tumor patients.
万方数据
维普
