Diagnostic value of imaging features and quantitative parameters of benign and malignant pulmonary nodules
[Objective]The imaging features and quantitative parameters of benign and malignant pulmonary nodules were analyzed in order to improve the accuracy of diagnosis.[Methods]Totally 95 cases of malignant pulmonary nodules and 44 cases of benign pulmonary nodules confirmed by operation and puncture biopsy were analyzed retrospectively.The difference of CT signs and quantitative parameters of benign and malignant pulmonary nodules was analyzed,and the Logistic regression model was constructed,receiver operating characteristic(ROC)curve was drawn,and area under curve(AUC)was calculated to distinguish benign and malignant pulmonary nodules.[Results]CT signs of benign and malignant pulmonary nodules showed no significant difference in bronchial sign,vacuole sign,spinous process sign and pleural depression sign(P＞0.05).There were significant differences in the lobular sign,burr sign and vascular bunching sign(P＜0.05).Quantitative parameters of benign and malignant pulmonary nodules including length diameter,volume ratio(volume ratio＜-300 HU,-300-50 HU,＞50 HU),total volume,mass ratio(mass ratio＜-300 HU,-300-50 HU,＞50 HU),total mass,maximum CT value and minimum CT value of the lesions,mean CT value,standard deviation and median had no statistical significance(P＞0.05).The differences of entropy,skewness and kurtosis were statistically significant(P＜0.05).Logistic regression analysis showed that entropy,skewness and kurtosis were independent predictors of benign and malignant pulmonary nodules.ROC curve showed that the AUC of the differential diagnosis value from high to low was 0.918,the threshold was 8.28,and the sensitivity and specificity were 89.47％and 88.64％,respectively.The AUC of skewness was 0.812,the threshold was-0.95,and the sensitivity and specificity were 83.16％and 75％,respectively.The AUC of kurtosis was 0.881,the threshold was 7.15,and the sensitivity and specificity were 88.42％and 81.82％,respectively.[Conclusion]Lobular sign,burr sign and vascular bunching sign are important imaging features of malignant pulmonary nodules.The entropy,skewness and kurtosis of CT quantitative parameters are of great value in distinguishing benign and malignant pulmonary nodules.
benign pulmonary nodulesmalignant pulmonary nodulesCT signs and quantitative parametersdifferential diagnosis
万方数据
维普
