[Objective]To investigate the difference in clinical prognosis of patients with new-onset heart failure(HF)and acute exacerbation of chronic heart failure(CHF)and analyze the influencing factors of clinical prognosis,so as to provide more reference for clinical diagnosis and treatment.[Methods]A total of 138 patients with acute HF were treated in our hospital from January 2020 to January 2022,including 55 patients with new-onset HF and 83 patients with acute exacerbation of CHF,who were considered as new-onset group and acute exacerbation group,respectively.The clinical characteristics and endpoint event occurrence between the two groups were compared,and univariate and multivariate methods were used to evaluate independent prognostic factors in patients with new-onset HF and acute exacerbation of CHF.[Results]In the new-onset group,physical index,systolic blood pressure level,diastolic blood pressure level,proportion of smoking,serum sodium level and the decrease of N-terminal brain natridium peptide precursor(NT-proBNP)were significantly higher than those of acute exacerbation group(P＜0.05).The 12-month composite endpoint event occurrence rate and all-cause mortality of the acute exacerbation group were significantly higher than those of the new-onset group(P＜0.05);the 12-month event-free survival rate of the acute exacerbation group was significantly lower than that of the new-onset group(P＜0.05);there was no statistically significant difference in the cumulative survival rate between the two groups after 12 months of follow-up(P＞0.05).The results of multivariate Cox regression model analysis showed that blood BNP level and NT-proBNP level at discharge were independent influencing factors for the occurrence of composite endpoint events in patients with new-onset HF during follow-up(P＜0.05);age and NT-proBNP level at discharge were independent influencing factors for the occurrence of composite endpoint events in patients with acute exacerbation of CHF during follow-up(P＜0.05).[Conclusion]Patients with acute exacerbation of CHF had worse clinical outcomes compared with new-onset HF;both categories were independently associated with NT-proBNP levels at discharge.
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