Teriparatide combined with unilateral PKP in treatment of osteoporotic thoracolumbar compression fractures
[Objective]To observe the clinical effect of teriparatide combined with unilateral percutaneous kyphoplasty(PKP)in the treatment of osteoporotic thoracolumbar compression fractures.[Methods]Sixty patients with osteoporotic thoracolumbar compression fractures were randomly divided into treatment group(n=30)and control group(n=30).The treatment group was treated with teriparatide combined with unilateral PKP,and the control group was treated with teriparatide combined with bilateral PKP.Cobb angle,anterior vertebral height(AVH),Oswestry disability index(ODI),Visual Analogue Scale(VAS)score,bone mineral density(BMD),amount of cement injected,operation time,number of intraoperative rays and bone cement leakage were used to evaluate the clinical efficacy.[Results]There were significant differences in Cobb angle,AVH,VAS score,ODI and lumbar BMD between the two groups one month and six months after treatment(P＜0.05).The operation time,X-ray frequency,infusion volume and cement leakage of the treatment group were significantly lower than those of the control group(P＜0.05).The improvement effect of the treatment group was significantly better than that of the control group(P＜0.05).[Conclusion]Teriparatide combined with unilateral PKP is a safe and effective method for the treatment of osteoporotic vertebral compression fractures(OVCFs),which can reduce the operation time and radiation exposure and increase bone mineral density.
teriparatidepercutaneous kyphoplastyosteoporotic thoracolumbar compression fracturebone mineral densitypain
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