Predictive efficacy of different inflammatory factors on ascites complicated by abdominal infection in liver cirrhosis
[Objective]To observe the predictive efficacy of different inflammatory factors on ascites complicated by abdominal infection in liver cirrhosis.[Methods]This article is a retrospective study,with cases included from January 2022 to June 2023.The study subjects were 118 patients with liver cirrhosis and ascites.According to whether they were complicated with abdominal infection,the enrolled patients were divided into an infected group(48 cases)and an uninfected group(70 cases).General and clinical data of the two groups of patients were collected and compared,and statistical univariate analysis was conducted.Logistic multiple factor regression analysis summarized the risk factors for complications of abdominal infection in patients with liver cirrhosis ascites.Spearman correlation coefficient was used to test the correlation between various inflammatory factors and the occurrence of abdominal infection in liver cirrhosis ascites.Receiver operating characteristic(ROC)curve was plotted and area under the curve(AUC)analysis was observed to predict the predictive power of various inflammatory factors on the occurrence of abdominal infection in liver cirrhosis ascites.[Results]The results of statistical univariate analysis showed that there were certain differences in general information such as smoking and drinking history,antiviral treatment,and clinical data such as inflammatory factors and immune indicators between the infected group and the non-infected group(P＜0.05).The results of logistic regression analysis showed that IL-6 ≥7 μg/mL,PCT ≥5 mg/L,SAA ≥35 mg/L,CD3+/CD4+≥40％,CD4+/CD8+≥1.5％were risk factors for ascites complicated with abdominal infection in liver cirrhosis.According to Spearman correlation coefficient test,inflammatory factors such as IL-6,PCT,and SAA are positively correlated with the incidence of abdominal infection in cirrhotic ascites.The ROC curve showed that the higher the expression of IL-6,PCT and SAA,the higher the risk of cirrhosis ascites complicated with abdominal infection.[Conclusion]Immune disorders caused by elevated levels of inflammatory factors such as IL-6,PCT,and SAA are risk factors for liver cirrhosis ascites complicated with abdominal infection.Dynamic monitoring of IL-6,PCT,and SAA can effectively predict abdominal infection.
万方数据
维普
