摘要
脊髓损伤(SCI)是一种严重的中枢神经系统创伤性疾病,可导致运动和感觉功能的丧失.由于其复杂的病理机制,该病的治疗仍面临着巨大的挑战.水凝胶具有良好的生物相容性和生物降解性,可以很好地模拟脊髓微环境中的细胞外基质.近年来,水凝胶被认为是一种很有前途的脊髓损伤修复材料,不断有研究证实,水凝胶治疗可以有效地消除炎症,促进脊髓修复和再生,从而改善脊髓损伤.本文总结近年来脊髓细胞外基质水凝胶的相关研究进展,以进一步阐明其在脊髓损伤修复中的具体作用机制,为脊髓损伤的治疗提供新方法.
Abstract
Spinal cord injury(SCI)is a severe traumatic disease of the central nervous system that can lead to loss of motor and sensory function.Due to its complex pathological mechanism,the treatment of this disease still faces great challenges.Hydrogels have good biocompatibility and biodegradability and can mimic the extracellular matrix in the spinal cord microenvironment.In recent years,hydrogel has been recognized as a promising material for spinal cord injury repair,and continuous research has confirmed that hydrogel therapy can effectively eliminate inflammation and promote spinal cord repair and regeneration,thereby improving spinal cord injury.This article summarizes the recent research progress of spinal extracellular matrix hydrogels to further elucidate their specific mechanism in spinal cord injury repair and provide a new method for the treatment of spinal cord injury.
基金项目
广西壮族自治区卫生健康委科技研究计划(Z20170030)
维普
万方数据