Effects of olaparib combined with bevacizumab regimen on short-term efficacy and serum P-selectin,sICAM-1 levels in patients with ovarian cancer
[Objective]To investigate the effects of combination therapy of olaparib and bevacizumab on the short-term efficacy,tumor markers,T lymphocytes,serum P-selectin,and soluble intercellular adhesion molecule-1(sICAM-1)in patients with ovarian cancer.[Methods]A total of 87 patients with ovarian cancer admitted to Anyang Cancer Hospital from January 2019 to May 2021 were selected as the study objects,and were divided into reference group(43 cases)and study group(44 cases)according to different treatment regimens.The reference group was treated with bevacizumab,and the study group was additionally treated with olaparib.Disease control rate(DCR),overall response rate(ORR)and incidence of toxic and side effects were compared between the two groups.The levels of vascular endothelial growth factor(VEGF),carbohydrate antigen(CA199,CA125),carcinoembryonic antigen(CEA),T lymphocytes(CD4+,CD8+,CD3+,CD4+/CD8+),P-selectin and sICAM-1 were compared before treatment and 30 days after treatment.[Results]After treatment,the ORR of the study group was 70.45％(31/44),higher than that of the control group[48.84％(21/43)],and the difference was statistically significant(P＜0.05).After treatment,the levels of CEA,CA199,VEGF,sICAM-1,P-selectin and CA125 were significantly decreased in both groups,and the decrease was more significant in study group(P＜0.05).Compared with those before treatment,the level of CD8+was increased,and the levels of CD4+,CD3+and CD4+/CD8+were decresed in the two groups(P＜0.05).After treatment,there were no statistically significant differences in the levels of CD8+,CD4+,CD3+and CD4+/CD8+between the two groups(P＜0.05).There was no significant difference in liver and kidney injury,thrombocytopenia,gastrointestinal reaction and mucosal bleeding between the two groups(P＞0.05).[Conclusion]Olaparib combined with bevalizumab is effective in the treatment of ovarian cancer,which can inhibit the formation of neovascularization,prevent the spread and metastasis of tumor cells,reduce the level of tumor markers and has a small impact on the body's immune function.
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