To investigate the efficacy of progesterone and metformin combined with mifepristone in treatment for endometrial cancer and its effect on reproductive hormones
[Objective]To investigate the effect of progesterone and metformin combined with mifepristone in the treatment of endometrial cancer and its influence on reproductive hormones.[Methods]Seventy-two patients admitted to the Second People's Hospital ofXinxiang due to endometrial cancer from January 2020 to December 2021 were selected using the random number table approach and were split into two groups:a control group(36 cases)and an observation group(36 cases).The control group was treated with progesterone and metformin for endometrial cancer,while the observation group received mifepristone in addition to the control group.The levels of reproductive hormones[follicle-stimulating hormone(FSH),luteinizing hormone(LH),prolactin(PRL),estradiol(E2),progesterone(P),testosterone(T)],tumor marker levels[serum carbohydrate antigen 125(CA125)and human epididymal protein 4(HE4)],quality of life(QOL)score of malignant tumor quality of life survey,and the curative effect were compared between the two groups.[Results]The disease remission rate was 83.33％in the observation group and 58.33％in the control group,and the difference was statistically significant(P＜0.05).After treatment,the levels of FSH,LH and T hormones in the observation group were lower than those in the control group,with statistical significance(P＜0.05).There was no statistical significance in the levels of PRL,E2 and P hormones between the observation group and the control group(P＞0.05).After treatment,the CA125 and HE4 values of both groups were decreased,and the CA125 and HE4 values of the observation group were lower than those of the control group,the difference was statistically significant(P＜0.05).After treatment,the quality of life of both groups was improved,and the improvement in the observation group was better than that in the control group,with statistical significance(P＜0.05).[Conclusion]In the treatment of endometrial carcinoma,progesterone and metformin combined with mifepristone can regulate the level of reproductive hormone,strengthen the effect of anticancer cells,inhibit and promote the apoptosis of cancer cells,improve the quality of life of patients,and have good clinical effects.
endometrial cancerprogesteronemetforminmifepristonereproductive hormonequality of lifetumor marker
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