Correlation analysis between inflammatory factors and sarcopenia in patients with metabolic syndrome
[Objective]To analyze the correlation between inflammatory factors and sarcopenia in patients with metabolic syndrome.[Methods]A total of 187 patients with metabolic syndrome admitted to our hospital from January 2019 to January 2022 were studied.They were divided into two groups based on whether they had sarcopenia.Among them,57 patients with sarcopenia were assigned to the sarcopenia group,while the remaining 130 patients without sarcopenia were assigned to the non-sarcopenia group.Univariate analysis was conducted on the various data of two groups of patients,logistic multivariate analysis was performed on statistically significant factors,the risk factors of metabolic syndrome patients with sarcopenia was analyzed,and the predictive effect of inflammatory factors on metabolic syndrome patients with sarcopenia was analyzed.[Results]Male proportion,age,nutritional risk/malnutrition proportion,course of disease,glycated hemoglobin,C-reactive protein,interleukin 6,tumor necrosis factor-α were higher,body mass index(BMI),left calf circumference,right calf circumference,left upper arm midpoint circumference,right upper arm midpoint circumference,skeletal muscle index(ASMI),grip strength,and gait speed were lower in the sarcopenia group than those in the non-sarcopenia group,with statistically significant differences(P＜0.05).Taking metabolic syndrome patients with sarcopenia as the dependent variable,assign values of 1=sarcopenia,0=no sarcopenia.All factors are derived from the index P＜0.05,take the median value of all samples as an independent variable to establish an unconditional logistic regression model.The results show that C-reactive protein ≥2.2 mg/L,interleukin 6 ≥6 ng/L,tumor necrosis factor-α ≥2.5 μg/mL are risk factors for sarcopenia in patients with metabolic syndrome(P＜0.05).C-reactive protein,interleukin 6,tumor necrosis factor-αlevels have certain predictive value for patients with metabolic syndrome complicated with sarcopenia.[Conclusion]C-reactive protein,interleukin 6,tumor necrosis factor-α levels are risk factors for patients with metabolic syndrome complicated with sarcopenia and have certain predictive value for the occurrence of sarcopenia.
万方数据
维普
