Peripheral perfusion indices to guide fluid resuscitation in patients with septic shock
[Objective]To analyze the peripheral perfusion indices for guiding fluid resuscitation in patients with septic shock.[Methods]Eighty patients with septic shock treated in Jinchang People's Hospital from May 2020 to August 2021 were enrolled in the study,and the patients were divided into an observation group(n=40)and a control group(n=40).The patients with septic shock in the control group were treated with conventional cluster therapy,and the patients with septic shock in the observation group were treated with peripheral perfusion index guidance during the treatment period.The mean arterial pressure,heart rate,central venous oxygen saturation,blood lactate,level of improvement in central venous pressure and intensive care unit mortality and mortality within 4 weeks,time to start negative fluid balance,24-h urine output,intensive care unit time,24-h fluid infusion,duration of mechanical ventilation and organ failure score between the two groups of septic shock patients before and after 6 hours of fluid resuscitation were compared and analyzed.[Results]Before fluid resuscitation,there were no significant differences in the mean arterial pressure,heart rate,central venous oxygen saturation,blood lactate,and central venous pressure between the two groups of patients with septic shock(P＞0.05),whereas after 6 hours of fluid resuscitation,the heart rate and blood lactate level were slightly lower in the observation group than in the control group,and the mean arterial pressure,central venous oxygen saturation,and central venous pressure were slightly higher in the observation group than in the control group,however,there were no significant differences in all the above indicators between the two groups of patients with septic shock(P＞0.05),the time to start negative fluid balance was significantly earlier in the observation group than in the control group(P＜0.05),the rates of mortality in the intensive care unit and within 4 weeks were lower in the observation group than in the control group,but there was no statistical significance in the comparison of data between groups(P＞0.05),in the observation group,the 24-h urine output was significantly higher than that of the control group,the 24-h fluid infusion volume and organ failure scores were significantly lower than those of the control group(P＜0.05),and the duration of intensive care unit and mechanical ventilation was significantly shorter than that of the control group(P＜0.05).[Conclusions]Early cluster therapy guided by peripheral perfusion index in septic shock patients is more beneficial in improving patients'vital signs,reducing mortality,and shortening patients'recovery time,with significant effects.
septic shockperipheral perfusion indexfluid resuscitationmentoring role
万方数据
维普
