Distribution characteristics,influencing factors,and drug resistance analysis of pathogenic bacteria for early onset sepsis in newborns at Zhengzhou Children's Hospital
[Objective]To analyze the distribution characteristics,influencing factors,and drug resistance of pathogens causing early onset sepsis in newborns at Zhengzhou Children's Hospital.[Methods]The clinical data of 63 newborns with early-onset sepsis admitted to Zhengzhou University Children's Hospital from February 2020 to February 2023 were served as the observation group and retrosepctively analyzed.A total of 63 non-septicemic newborns admitted to the hospital during the same period were selected as the control group.The distribution of pathogenic bacteria in newborns with early-onset sepsis was analyzed.Univariate and multivariate analysis on the influencing factors of early onset sepsis was conducted.Drug resistance analysis on the main pathogens of neonatal infection with early-onset sepsis was conducted.[Results]A total of 63 strains of pathogenic bacteria were detected in the observation group of children,among which Staphylococcus epidermidis and Staphylococcus aureus accounted for a high proportion of Gram positive bacteria,accounting for 22.22％and 11.11％,respectively.Escherichia coli and Klebsiella pneumoniae account for a high proportion of Gram negative bacteria,with 26.98％and 14.29％,respectively.The proportion of premature rupture of membranes,prenatal fever,extremely low birth weight of newborns,umbilical infections,and pulmonary infections in the observation group was significantly higher than that in the control group(P＜0.05).Premature rupture of membranes in pregnant women,prenatal fever in pregnant women,extremely low birth weight of newborns,umbilical infection in newborns,and pulmonary infection in newborns are independent risk factors for the onset of early-onset sepsis in newborns(P＜0.05).Among the pathogens causing early onset sepsis in newborns,Staphylococcus epidermidis has a resistance rate of 28.57％to ampicillin,and the highest proportion is penicillin with a resistance rate of 28.57％.The resistance of Escherichia coli to ampicillin and amoxicillin was 29.41％,followed by 23.53％of clarithromycin and 17.65％of cefazolin.[Conclusion]When treating early-onset sepsis,it is necessary to clarify the type of pathogenic bacteria infected by the child and provide appropriate treatment plans based on drug sensitivity results.At the same time,there are many influencing factors for the onset of early-onset sepsis,and timely targeted prevention is needed to reduce the occurrence of the disease.
early onset sepsisdistribution of pathogenic bacteriarisk factorsresistance
万方数据
维普
