Relationship between TIPE2,Cath-D,GPX3 and incidence of PTC and correlation of predicting postoperative recurrence
[Objective]To investigate the correlation between tumor necrosis factor-alpha-induced protein 8-like 2(TIPE2),cathepsin D(Cath-D),glutathione peroxidase 3(GPX3)and the incidence and postoperative recurrence of papillary thyroid carcinoma(PTC).[Methods]A total of 176 patients with PTC who received surgical treatment in Xinxiang Central Hospital from June 2020 to December 2021(all completed 1-year follow-up)were selected as the PTC group,and 176 patients with benign thyroid nodules during the same period were selected as the control group.According to the recurrence of PTC patients 1 year after surgery,they were divided into two subgroups:recurrence(64 cases)and non-recurrence(112 cases).The expressions of TIPE2,Cath-D and GPX3 in the two groups were compared,the expressions of TIPE2,Cath-D and GPX3 in the cancer tissues of patients with recurrence and those without recurrence were compared,and the expressions of TIPE2,Cath-D and GPX3 in the cancer tissues of patients with different pathological parameters PTC were compared.The correlation between the expression of TIPE2,Cath-D and GPX3 in tissues and the incidence of PTC,pathological parameters of PTC and postoperative recurrence was analyzed,and the influencing factors of postoperative recurrence in PTC patients were analyzed by partial regression.[Results]The positive expression rates of TIPE2 and GPX3 in PTC group were lower than those in control group,and the positive expression rate of Cath-D in PTC group was higher than that in control group(P＜0.05).The positive expression rates of TIPE2 and GPX3 in patients with recurrence were lower than those without recurrence,and the positive expression rate of Cath-D was higher than that without recurrence(P＜0.05).The positive expression rates of TIPE2 and GPX3 in cancer tissues of PTC patients with different pathological parameters were higher in stage Ⅰ to Ⅱ than in stage Ⅲ to Ⅳ,higher in high and medium differentiation than in low differentiation,higher in no lymph node metastasis than in lymph node metastasis(P＜0.05).The incidence,recurrence,clinical stage,differentiation degree and lymph node metastasis of PTC were negatively correlated with the positive expression rate of TIPE2 and GPX3 in tissues,and positively correlated with the positive expression rate of Cath-D(P＜0.05).Logistic regression analysis showed that the positive expression of TIPE2 and GPX3 in cancer tissue was a protective factor for postoperative recurrence in PTC patients,and the positive expression of Cath-D was a risk factor(P＜0.05).[Conclusion]The positive expression rates of TIPE2,Cath-D and GPX3 in tissues are related to the occurrence and development of PTC,and are the influencing factors for postoperative recurrence of PTC patients.
万方数据
维普
