Clinical effect of local injection of nerve growth factor and root canal therapy in treating pulpitis
[Objective]To study the clinical effect of local injection of nerve growth factor(NGF)and root canal therapy in treating pulpitis.[Methods]Ninety-two cases of pulpitis patients were divided into observation group and control group with 46 cases(46 teeth)in each group,patients were given root canal therapy.The control group was given metronidazole tablets,the observation group was given NGF local injection on the basis of control group,both groups were treated for 10 d.The efficacy,periodontal index,and adverse reactions between the two groups were compared.[Results]The total response rate in the observation group was higher than the control group(P＜0.05).The gingival index(GI),periodontal pocket depth(PD)and sulcus bleeding index(SBI)scores were significantly lower than before treatment,and the observation group was lower than the control group(P＜0.05).The overall incidence of adverse effects in the observation group was significantly lower than the control group(P＜0.05).[Conclusion]The combination of NGF local injection and root canal therapy has a good clinical effect on patients with pulpitis,can effectively improve the periodontal symptoms,and has a high safety.
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