Ischemic heart disease is one of the most important causes of death in the world,and myocardial ischemia reperfusion injury(MIRI)is a common complication of ischemic heart disease.Currently,there is no effective treatment for MIRI.Over the past few decades,oxycodone has not only been widely used as an analgesic,but also has been found by many studies to have a certain effect on the protection of MIRI of myocardial tissue.This review mainly focuses on the therapeutic and preventive effects of oxycodone on MIRI by inhibiting oxidative stress,inhibiting the expression of inflammatory factors,and protecting the integrity of myocardial endothelial cells.The purpose of this paper is to review the published mechanisms of oxycodone in MIRI and provide references for further research in this field.
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