Influence of serum C-reactive protein and procalcitonin on coronary heart disease and poor prognosis in the elderly
[Objective]To investigate the potential of serum C-reactive protein(CRP)and procalcitonin(PCT)in predicting elderly coronary heart disease(CHD)and their impact on prognosis.[Methods]This retrospective analysis included 180 elderly patients with coronary heart disease(coronary heart disease group)and 200 patients without cardiovascular disease(control group).Coronary heart disease patients underwent 12 months of follow-up after discharge.Patients who were readmitted due to adverse cardiovascular events were included in the group with poor prognosis,while the remaining patients were considered in the group with good prognosis.Compare the serum CRP and PCT levels between the coronary heart disease group and the control group,and analyze the diagnostic value of CRP and PCT for coronary heart disease and poor prognosis using the receiver operating characteristic(ROC)curve.[Results]The serum CRP and PCT levels in the coronary heart disease group were significantly higher than those in the control group.Logistic regression analysis showed that serum CRP and PCT are related factors for coronary heart disease.The areas under the ROC curve for CRP,PCT,and their combined diagnosis of coronary heart disease were 0.858(95％CI:0.822-0.893,P＜0.001),0.762(95％CI:0.713-0.812,P＜0.001),and 0.922(95％CI:0.894-0.950,P＜0.001),respectively.The CRP and PCT levels in the group with poor prognosis were significantly higher than those in the group with good prognosis.The areas under the ROC curve for poor prognosis in patients with coronary heart disease diagnosed by CRP,PCT,and their combination were 0.750(95％CI:0.703-0.797,P＜0.001),0.651(95％CI:0.597-0.705,P＜0.001),and 0.859(95％CI:0.823-0.894,P＜0.001),respectively.[Conclusion]The serum PCT and CRP levels in elderly patients with coronary heart disease are abnormally elevated,and higher levels are associated with a higher risk of coronary heart disease and poor prognosis.The determination of PCT and CRP is of great significance for guiding clinical treatment.
万方数据
维普
