Composition and risk of urolithiasis in HIV infected individuals treated with indinavir
[Objective]To investigate the correlation between the use of indinavir and the incidence of urolithiasis in human immunodeficiency virus(HIV)infected individuals,and analyze the differences in stone composition between patients taking indinavir and those taking other anti-HIV retroviral drugs,so as to provide reference for the clinical prevention and treatment of urolithiasis in HIV infected patients.[Methods]The clinical data of 1150 HIV infected patients admitted to the First Hospital of Changsha from July 2016 to January 2023 were retrospectively analyzed.They were divided into two groups:the treatment group with indinavir(observation group)and the treatment group with other anti-HIV retroviral drugs(control group).The incidence rate of urolithiasis in the two groups were compared.Totally 180 stone samples were collected for calculus composition analysis,and the composition and difference of calculus composition between the two groups were analyzed.[Results]The incidence rate of urolithiasis in the observation group was significantly higher than that in the control group(P＜0.05).Both groups of stones were mainly composed of calcium oxalate,and there was no significant difference in the distribution of calcium phosphate,magnesium ammonium phosphate,and uric acid stones(P＞0.05).However,the observation group had fewer calcium oxalate stones compared with the control group,and the number of indinavir induced stones was significantly increased compared with the control group(P＜0.05).There was no significant difference in the recurrence rate between the two groups after 6 months of stone treatment(P＞0.05).[Conclusion]Taking indinavir to treat HIV infection increases the risk of urinary tract stones.The composition and recurrence rate of stones are not significantly different from those of patients taking other anti HIV drugs.Therefore,personalized prevention and treatment plans should be developed based on the analysis of stone components to reduce stone recurrence rate and improve treatment effectiveness.However,the incidence of drug-induced stones,namely indinavir stones,is higher than that of other drug groups.Hydrating urine during medication is an important measure to reduce the recurrence of urinary system stones.
indinavirhuman immunodeficiency virusurolithiasisanalysis of calculus compositionrisk of disease
万方数据
维普
