Mechanism study on the treatment of hepatocellular carcinoma with flavonoids from Scutellaria barbata D.Don based on network pharmacology and molecular docking
[Objective]To explore the mechanism of action and molecular docking technology validation of flavonoids from Scutellaria barbata D.Don in the treatment of hepatocellular carcinoma using network pharmacology methods.[Methods]Flavonoids and liver specific targets were screened through databases such as TCMSP,SwissTargetPrediction,OMIM,and BioGPS.A liver specific target protein interaction network was constructed,and core modules and genes were screened.Enrichment analysis of liver specific target biological pathways was conducted.Molecular docking of flavonoids and core protein targets was performed on the SwissDock platform.[Results]There were 36 flavonoid components,135 liver specific targets,and 4 core genes.Key biological pathways are all associated with the proliferation inhibition of hepatocellular carcinoma.Flavonoids have strong binding activity with core targets.[Conclusion]The anti-tumor effect of flavonoids from Scutellaria barbata D.Don may be achieved by blocking the Gl/S cell cycle of liver cancer cells through multiple components and targets,thereby inhibiting the proliferation of liver cancer cells.
万方数据
维普
