Relationship between RELT mRNA levels and prognosis in cancer tissues and adjacent normal tissues of patients with esophageal squamous cell carcinoma
[Objective]To investigate the relationship between receptor expressed in lymphoid tissue(RELT)mRNA content and prognosis in cancer tissues and adjacent normal tissues of patients with esophageal squamous cell carcinoma(ESCC).[Methods]A hundred ESCC tissue samples surgically removed in Xinyang Central Hospital from January 2019 to January 2021 were collected as the observation group,and the corresponding normal tissues adjacent to cancer(larger than 5 cm away from cancer tissues)were selected as the control group,and the relative expression levels of RELT mRNA in the two groups were compared.According to the median RELT mRNA expression,ESCC patients were divided into 2 groups with low expression(45 cases)and high expression(55 cases).The difference of clinical data between the two groups was compared.The patients with ESCC were followed up for 24 months,and the survival time of the two groups was compared by drawing Kaplan-Meier curve.Multivariate COX proportional hazard regression model was used to analyze the risk factors of poor prognosis in ESCC patients.[Results]The relative expression levels of RELT mRNA and RELT protein in ESCC patients in observation group were 8.03±2.31 and 0.87±0.08,which were higher than those in control group(3.05±0.71 and 0.63±0.07)(P＜0.05).Using the median RELT mRNA expression of 8.05 as the cut-off value,100 ESCC patients were divided into high expression group(≥8.05)and low expression group(＜8.05).The incidence of age＜60 years old,tumor invasion depth T3+T4,TNM stage ⅡB-Ⅲ,lymph node metastasis and vascular invasion in ESCC patients in high expression group were higher than those in low expression group(P＜0.05).After 24 months of follow-up,the survival time of ESCC patients in the high RELT mRNA expression group was 15.85±1.02 months,and the survival time of ESCC patients in the low RELT mRNA expression group was 19.71±0.84 months.The survival time of ESCC patients in the high RELT mRNA expression group was shorter than that in the low RELT mRNA expression group(log-rank test x2=6.371,P=0.012＜0.05).TNM stages ⅡB to Ⅲ((O)R=1.377,95％CI:1.032-1.837)and RELT mRNA relative expression ≥8.05((O)R=1.420,95％CI:1.057-1.910)were risk factors for poor prognosis of ESCC(P＜0.05).[Conclusion]The increased expression of RELT mRNA in ESCC cancer tissues is associated with poor prognosis of patients,and can be used as a potential target for prognosis prediction and treatment of ESCC.
esophageal squamous cell carcinomareceptor expressed in lymphoid tissueprognosisrisk factor
万方数据
维普
