Research progress on the mechanism of indoxyl sulfate promoting acute coronary syndrome in patients with chronic kidney disease
Acute coronary syndrome(ACS)is one of the leading causes of death in patients with chronic kidney disease(CKD),especially in uremic patients,and the main causes of ACS are atherosclerosis and intra-arterial thrombosis due to endothelial damage.Indoxyl sulfate(IS)is a metabolite of tryptophan under the action of intestinal bacteria.In CKD patients,especially in uremic patients,IS cannot be excreted effectively,causing accumulation in the body and causing endothelial function damage in several ways and playing an important role in the development of ACS.In this paper,we review the recent progress of endothelial injury and thrombosis mechanisms in CKD patients caused by IS,and summarize the new measures to mitigate IS-induced ACS in CKD patients,in order to help prevent and treat cardiovascular events in CKD patients.
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维普
