Application value of autologous BMSCs transplantation in core decompression surgery for elderly femoral head necrosis
[Objective]To observe the application effect of autologous BMSCs transplantation in elderly osteonecrosis of the femoral head(ONFH)core decompression surgery.[Methods]This study is a prospective study that selected 113 elderly patients with ONFH admitted between January 2022 and May 2023 as the study subjects.They were randomly divided into an experimental group(57 cases)and a control group(56 cases)using computer randomization.The control group received traditional core decompression surgery,while the experimental group received autologous bone mesenchymal stem cells(BMSCs)transplantation combined with core decompression surgery.The surface molecules of BMSCs,bone metabolism levels,bone density,area of bone necrosis,hip joint function and pain symptoms before and after treatment were compared between the two groups.[Results]Under different treatment regimens,the expression levels of CD34,CD105,and CD166 molecules in BMSCs in the experimental group were 2.48％±0.76％,13.36％±3.27％,and 37.49％±5.28％,higher than those in the control group(1.92％±0.36％,11.45％±2.13％,and 34.23％±5.16％)(P＜0.05).The OPG,BGP,and FGF-2 levels in the experimental group were 5.45±1.36 pg/mL and 6.27±1.45 μg/mL,43.35±10.46 ng/L,higher than the control group(4.41±1.36 pg/mL,5.52±1.44 μg/mL,37.25±10.41 ng/L)(P＜0.05).The bone mineral density of the experimental group at 1 month and 3 months after surgery was 0.32±0.11 g/cm2 and 0.49±0.23 g/cm2,higher than those of the control group(0.25±0.11 g/cm2 and 0.35±0.16 g/cm2)(P＜0.05).The area of bone necrosis was 26.44％±5.17％and 20.45％±5.23％,lower than that of the control group(29.12％±5.33％and 23.32％±5.18％)(P＜0.05).The VAS scores of the experimental group at 1 month and 3 months after surgery were 4.25±1.27 points and 2.82±0.46 points,lower than those of the control group(5.33±1.77 points and 3.21±0.52 points)(P＜0.05).The Harris scores of the experimental group at 1 month and 3 months after surgery were 70.33±10.32 points and 85.66±10.45 points,higher than those of the control group(65.22±10.36 points and 80.33±10.71 points)(P＜0.05).[Conclusion]Autologous BMSCs can improve the bone metabolism level of elderly ONFH patients by upregulating the surface molecules of bone marrow hepatocytes.Autologous BMSCs transplantation combined with core decompression can effectively increase the bone density level of patients and reduce the area of bone necrosis,which has positive significance in alleviating hip joint pain,promoting hip joint function recovery.
elderly femoral head necrosiscore decompression surgeryautologous bone marrow mesenchymal stem cellsbone metabolismhip joint function
万方数据
维普
