Differential value of DCE-MRI parameters combined with serum PSA levels in differentiation of prostate cancer
[Objective]To analyze the differential value of dynamic contrast enhanced magnetic resonance imaging(DCE-MRI)parameters combined with serum prostate specific antigen(PSA)level in differentiation of prostate cancer.[Methods]The clinical data of 148 prostate cancer patients admitted to Anyang People's Hospital from March 2020 to January 2023 were retrospectively analyzed,and they were all tested for DCE-MRI and serum PSA level before treatment.The prostate cancer patients were divided into poorly differentiated group(score ≥8 points)and moderately and well differentiated group(score＜8 points)based on Gleason rating.The DCE-MRI parameters[rate constant(Kep),transport constant(Ktrans),extracellular volume fraction(Ve)]and serum PSA level in two groups were compared,and the receiver operating characteristic(ROC)curve was used to analyze the differential value of DCE-MRI parameters combined with serum PSA level in differentiation of prostate cancer.[Results]The Kep,Ktrans,Ve and serum PSA level in the poorly differentiated group were higher than those in the moderately and well differentiated group(P＜0.05).The sensitivity,specificity and area under curve(AUC)of the combined identification of DCE-MRI parameters were 85.00％,67.05％and 0.793,respectively.The sensitivity,specificity and AUC of the combined identification of DCE-MRI parameters and serum PSA level were 80.00％,88.64％and 0.872,respectively.[Conclusion]The poorly differentiated prostate cancer has higher Kep,Ktrans,Ve and serum PSA level compared with moderately and well differentiated prostate cancer,and the combination identification of the above indicators has good effectiveness,which is suitable for clinical use.
dynamic contrast enhanced magnetic resonance imagingprostate-specific antigenprostatic cancerdifferentiation gradeidentification value
万方数据
维普
