Risk factors of bronchial mucus thrombus formation in children with lobar pneumonia and their predictive efficacy
[Objective]To investigate the risk factors of bronchial mucus thrombus formation in children with lobar pneumonia and their predictive efficacy,in order to provide more reference for early identification of poor prognosis population and prevention and treatment.[Methods]Seventy-eight children with lobar pneumonia were retrospectively chosen in the period from July 2021 to May 2023.All patients were divided into formation group(19 cases)and non-formation group(59 cases)according to bronchial mucus thrombus formation or not.The independent risk factors for bronchial mucus thrombus formation in children with lobar pneumonia were evaluated by univariate and multivariate methods.The clinical efficacy of these independent risk factors in predicting the risk of bronchial mucus thrombus formation in children with lobar pneumonia were further evaluated.[Results]The results of univariate analysis showed that age,fever duration,neutrophil percentage,C-reactive protein level,procalcitonin level,D-dimer level,lactate dehydrogenase level,CD4+and CD8+T lymphocyte count ratio,bacterial infection and Epstein-Barr virus infection may be related to the formation of bronchial mucus thrombus in children with lobar pneumonia(P＜0.05).Multivariate analysis of logistic regression model showed that high lactate dehydrogenase and high CD4+to CD8+T lymphocyte count ratio were independent risk factors for bronchial mucus thrombus formation in children with lobar pneumonia(P＜0.05).Receiver operating characteristic(ROC)curve analysis showed that both lactate dehydrogenase and CD4+to CD8+T lymphocyte count ratio could be used to predict the risk of bronchial mucus thrombus formation in children with lobar pneumonia,and the combined efficacy of both was better than that of single use(P＜0.05).[Conclusion]The formation of bronchial mucus thrombus in children with lobar pneumonia was independently correlated with lactate dehydrogenase and CD4+to CD8+T lymphocyte count ratio.The combination of the two methods can more accurately predict the risk of bronchial mucus thrombus formation in children with lobar pneumonia.
万方数据
维普
