Effects of antiplatelet drug in treating intracranial aneurysm on neurological function,the level of serum sICAM-1 and prognosis after interventional surgery
[Objective]To explore the effects of antiplatelet drug in treating intracranial aneurysm on neurological function,the level of serum sICAM-1 and prognosis after interventional surgery.[Methods]A total of 98 patients with cerebral aneurysm admitted to the First Affiliated Hospital of Henan University of Science & Technology from June 2020 to June 2022 were randomly divided into a test group of 49 cases and a matched group of 49 cases using a random number table method.Both groups underwent cerebral aneurysm stent-assisted embolization,and the patients in the control group were given routine anticoagulant therapy,while those in the observation group were given antiplatelet drug therapy.The nerve function,the levels of serum adhesion factor and postoperative complication rate were compared between the two groups.[Results]After treatment,compared with the control group,the levels of myelin basic protein(MBP),neuron specific enolase(NSE)and matrix metalloproteinase metalloproteinase-9(MMP-9)in the observation group were significantly lower than those in the control group(P＜0.05).After treatment,the levels of soluble intercellular adhesion molecule-1(sICAM-1)and soluble vascular cell adhesion molecule-1(sVCAM-1)in the observation group were lower than those in the control group(P＜0.05).After treatment,the incidence of postoperative complications was 6.12％(3 cases/49 cases)in the observation group and 20.41％(10 cases/49 cases)in the control group(P＜0.05).[Conclusion]The combined antiplatelet drug therapy after interventional surgery in cerebral aneurysm plays a very significant role in regulating nerve function and the levels of serum adhesion factor,and improving nerve function,it can help eliminate the ischemic complications caused by thrombosis and accelerate the recovery of brain function in cerebral aneurysm patients.
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