Effect of hemodialysis and hemoperfusion on diabetic nephropathy and its influence on adipokines and inflammatory factors
[Objective]To analyze the effect of hemodialysis and hemoperfusion on adipokines and inflammatory factors in patients with diabetes nephropathy(DN).[Methods]Eighty patients with DN admitted to Jiyuan People's Hospital were randomly divided into an experimental group and a control group,with 40 cases in each group.They were treated with hemodialysis and hemoperfusion therapy,as well as hemodialysis combined with hemodialysis filtration therapy.[Results]The total effective rate of 67.50％in the experimental group was significantly higher than that of 42.50％in the control group,and there was a significant difference in clinical efficacy between the two groups(P＜0.05).After treatment,the experimental group showed significant improvement in the levels of fat factor resistin,adiponectin,and leptin compared with the control group.Inflammatory factors such as tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP),and interleukin-6(IL-6)decreased significantly compared with the control group.After treatment,there was a significant difference in adipose factors and inflammatory factors between the two groups(P＜0.05).[Conclusion]Hemodialysis combined with hemoperfusion therapy can improve the clinical efficacy of DN patients and effectively improve adipocytokines and inflammatory factors.
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维普
