Effect of donepezil combined with memantine hydrochloride and nimodipine in treatment of elderly dementia and its impact on memory function and cerebral microcirculation
[Objective]To analyze the efficacy of donepezil in combination with memantine hydrochloride and nimodipine in elderly dementia.[Methods]During the period from January 2021 to July 2022,62 elderly dementia patients treated in Luoyang Dongfang People's Hospital were selected and randomly divided into two groups.The control group consisted of 31 patients(memantine hydrochloride and donepezil),and the treatment group consisted of 31 patients(donepezil combined with memantine hydrochloride and nimodipine).The treatment effects,memory function score and brain microcirculation indicators were compared.[Results]The total effective rate of treatment in the treatment group was significantly higher than that in the control group(P＜0.05);after therapy,the scores of memory function in all dimensions in the treatment group were higher than those in the control group(P＜0.05);after therapy,the blood flow of the right vertebral artery,left vertebral artery,and basilar artery in the treatment group was higher than that in the control group(P＜0.05).[Conclusion]The combination of donepezil,memantine hydrochloride,and nimodipine has a satisfactory therapeutic effect on elderly dementia,which can improve patients'memory function and cerebral microcirculation,and is worthy of promotion and application.
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