Effect of exenatide on type 2 diabetes and its influence on insulin resistance and glucose and lipid metabolism
[Objective]To analyze the effect of exenatide on type 2 diabetes patients(insulin resistance index,glucose and lipid metabolism index).[Methods]Eighty-two patients with type 2 diabetes treated in Xinxiang Second People's Hospital from February 2021 to February 2023 were selected.They were divided into a control group and a study group(41 cases each)by random number table method.The control group was treated with metformin,while the study group was treated with exenatide(on the basis of the control group).The two groups were treated continuously for 28 days.The clinical efficacy(after treatment)and incidence of adverse reactions(during treatment)were compared between the two groups,as well as glucose and lipid metabolism,insulin resistance,and inflammation indicators(before and after treatment).[Results]The total effective rate of the study group was higher than the control group(P＜0.05).The levels of serum total cholesterol(TC),fasting blood glucose(FPG),fasting insulin(FINS),postprandial 2-hour blood glucose(2-hour PG),high mobility group protein 1(HMGB1),triacylglycerol(TG),interleukin-6(IL-6),insulin resistance index(HOMA-IR),and transforming growth factor-β(TGF-β)all decreased after treatment compared with before treatment,and the study group was at a lower level compared with the control group(P＜0.05).The total incidence of adverse reactions(during treatment)between the two groups was compared with no signifiicant difference(P＞0.05).[Conclusion]Treatment of type 2 diabetes with exenatide is helpful to improve the clinical efficacy of patients with type 2 diabetes,and regulate the indicators of glucose and lipid metabolism(serum FPG,2hPG,TC,TG)and inflammatory reaction index levels(serum TGF-β,HMGB1 and IL-6),which can alleviate clinical symptoms,improve pancreatic function,and have fewer adverse reactions.
type 2 diabetesexenatideinsulin resistanceglycolipid metabolisminflammatory responsesecurity
万方数据
维普
