Expression of N-MID,Ghrelin,and miR-133a in traumatic fractures and their correlation with delayed healing
[Objective]To investigate the expression of N-MID,Ghrelin,and miR-133a in traumatic fractures and their correlation with delayed healing.[Methods]Sixty patients with delayed healing of traumatic fractures admitted to Dushan Campus of Nanyang Traditional Chinese Medicine Hospital from June 2022 to June 2023 were selected as the study subjects,and another 60 patients with normal healing were selected as the control group.The levels of N-MID,Ghrelin,and miR-133a in the serum of two groups of patients were compared,and their correlation with delayed healing was analyzed.[Results]The levels of N-MID and Ghrelin in the study group were lower than those in the control group,and the levels of miR-133a were higher than those in the control group(P＜0.05).The levels of N-MID and Ghrelin in stage Ⅲ and IV patients were lower than those in stage Ⅱpatients,and miR-133a was higher than that in stage Ⅱ patients(P＜0.05).The levels of N-MID and Ghrelin in stage Ⅳ patients were lower than those in stage Ⅲ patients,and miR-133a was higher than that in stage Ⅲ patients(P＜0.05).The levels of N-MID and Ghrelin in patients with traumatic fractures were positively correlated(r=9.409,P=0.003).The levels of N-MID and miR-133a were negatively correlated(r=-6.442,P-=0.013).The levels of Ghrelin and miR-133a were negatively correlated(r=-5.677,P=0.019).N-MID and Ghrelin are positively correlated with delayed healing of traumatic fractures,while miR-133a is negatively correlated with delayed healing of traumatic fractures.[Conclusion]The levels of N-MID,Ghrelin,and miR-133a are all related to the degree of healing of traumatic fractures.Overexpression of miR-133a inhibits the levels of N-MID and Ghrelin in patients with traumatic fractures,thereby affecting the normal healing of fractures.Detecting serum N-MID can evaluate the recovery of traumatic fractures,and Ghrelin can serve as a potential marker for predicting delayed healing of traumatic fractures.
N-terminal intermediate molecular fragments of serum osteocalcinGhrelinmicro RNA-133atraumatic fracture
万方数据
维普
