Effect of alanine-glutamine intensive nutritional support combined with ulinastatin on body immunity and prognosis after gastric cancer resection treatment
[Objective]To investigate the effects of alanine glutamine fortified nutritional support combined with ulinastatin on the immune system,hemodynamics,and prognosis of patients with septic shock after gastric cancer resection treatment.[Methods]Ninety-eight patients with septic shock after gastric cancer resection treatment at Zhengzhou People's Hospital from July 2019 to December 2020 were selected as the subjects.They were randomly divided into an experimental group and a control group,with 49 patients in each group.Both groups were treated with conventional methods,the control group received alanine glutamine enhanced nutritional support intervention,while the observation group received combined treatment with ulinastatin injection.After 4 weeks of treatment,the patient's efficacy was evaluated,and the immune system,hemodynamics,prognosis,and drug safety between the two groups were compared.[Results]Before treatment,there was no significant difference in the levels of helper T cells(CD4+),cytotoxic T cells(CD8+),helper T cells/cytotoxic T cells(CD4+/CD8+),immunoglobulin A(IgA),and immunoglobulin G(IgG)between the experimental and control groups(P＞0.05).After treatment,the levels of various indicators in the experimental group were significantly higher than those in the control group(P＜0.05).Before treatment,there was no significant difference in the systemic vascular resistance index(SVRI),extravascular lung water index(EVLWI),and pulmonary vascular permeability index(PVPI)between the experimental group and the control group(P＞0.05).After treatment,the experimental group had significantly lower indicators than the control group(P＜0.05).The mortality rate within 6 months after treatment in the experimental group was significantly lower than that in the control group(P＜0.05).Before treatment,there was no significant difference in IL-6,IL-8,TNF-α between the experimental and control group(P＞0.05).After treatment,all indicators in both groups showed a significant decrease,with the experimental group showing a significant decrease compared with the control group(P＜0.05).There was no statistical difference in the incidence of liver and kidney abnormalities,diarrhea,constipation,itching,rash allergies,and eosinophilia between the two groups during the medication period(P＞0.05).[Conclusion]The combination of alanine glutamine fortified nutritional support and ulinastatin in patients with septic shock after gastric cancer resection treatment can help enhance patient immunity,improve hemodynamics and prognosis,and the drug has high safety,which is worth promoting and applying.
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