Assisted repair of rabbit skull injury defect with absorbable skull fixing lock
[Objective]Using New Zealand rabbits as an animal model,to evaluate the safety and effectiveness of using absorbable skull locks to repair rabbit skull defects by observing the physiological state,clinical manifestation and pathological histological changes of model animals after using absorbable skull fixed locks.[Methods]According to the requirements of the experimental purpose and experimental design,105 New Zealand rabbits were randomly divided into test groups,control groups and blank control groups.Test groups and control groups respectively underwent skull defects,and were implanted with test products and contrast materials,while blank control groups only had defects and no materials implanted.The animals were sacrificed at 1 month,2 months,3 months,6 months,9 months,12 months and 15 months after surgery for anatomical observation and histopathological analysis.During the study,all animals were clinically observed.[Results]During the study,there were no obvious clinical abnormalities in each group,and there was no animal death.The weight was significantly increased during 9 to 15 months after surgery,and the detection of blood routine and serum biochemistry tests had no significant abnormalities.In the observation of anatomy animals at each time points,the tissue around the implant site was normal,and the absorbable skull fixed lock could be gradually fused with surrounding bone at various time points.The binding degree between it and animal autogenous bone was becoming increasingly close,which can effectively perform bone flap reset,promote cranial healing,and no infectious inflammatory response was found by pathological histological examination.[Conclusion]Under the conditions of this trial,the absorbable skull fixed lock in repairing rabbit skull defect has similar repair results compared with the control group and can effectively perform bone flap reset,and rabbit model test proves clinical safety.
absorbable skull fixing lockskull defectrabbit model
万方数据
维普
