Correlation of ApoE/SLCO1B1 gene polymorphisms with lipid levels and statins in hyperlipidemic population in Xiaogan area
[Objective]To investigate the polymorphism distribution of ApoE and SLCO1B1 gene loci in hyperlipidemia population in Xiaogan area,study the correlation between different loci of the gene and lipid level from the molecular level,evaluate the efficacy of personalized statin drug administration,and provide theoretical basis for the individualized prevention and treatment of hyperlipidemia.[Methods]Nine hundred patients in Xiaogan Central Hospital from July 2022 to July 2023 were selected as the study objects,and the blood lipid indexes of all patients were determined,including triglyceride (TG),total cholesterol (TC),high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C),and very low density lipoprotein cholesterol (VLDL-C).The polymorphism of ApoE2 (526C>T) and ApoE4 (388T>C) locus of ApoE gene and SLCO1B1*1b (388A>G) and SLCO1B1*5 (521T>C) locus of SLCO1B1 gene were qualitatively detected by real-time fluorescence quantitative PCR method,which were compared with the reported data of hyperlipidemics from other regions in China,and the differences in genotype distribution among different regions were analyzed.[Results]The distribution frequency of ApoE genotype in dyslipidemia population was E2/E2 (0.34％),E2/E3 (14.00％),E3/E3 (68.89％),E3/E4 (13.22％),E2/E4 (1.78％) and E4/E4 (1.78％).SLCO1B1 genotype frequency:*1a/*1a (7.22％),*1a/*1b (32.89％),*1b/*1b (39.22％),*1a/*5 (0.11％),*1a/*15 (6.22％),*1b/*15 (13.00％),*15/*15 (1.33％).[Conclusion]E3/E3 genotype accounted for the largest proportion of ApoE in Xiaogan area,and *1b/*1b genotype in SLCO1B1 gene accounted for the highest proportion,that is,after the use of statins in hyperlipidemia population in Xiaogan area,most of them had a good effect and a low risk of myopathy.The E4 gene frequency distribution of ApoE genotype had statistical significance with blood lipid level (P<0.05).There was no significant difference between ApoE/SLCO1B1 and lipid levels (P>0.05).
万方数据
维普
