Effects of polyene phosphatidylcholine on the progression and prognosis of hepatic fibrosis in hepatitis B cirrhosis
[Objective]To observe the effect of polyene phosphatidylcholine on the progression and prognosis of liver fibrosis in patients with hepatitis B cirrhosis.[Methods]This study is a prospective study.A total of 101 patients with hepatitis B cirrhosis who were admitted from June 2021 to July 2023 were selected as the study objects.They were randomly divided into the conventional group (50 cases) and the experimental group (51 cases) by computer.The conventional group was treated with conventional drugs,and the experimental group was treated with polyene phosphatidylcholine.The improvement of viral load level,liver fibrosis indicators,liver function indicators,inflammatory indicators and prognosis were compared between the two groups.[Results]Under different treatment plans,the viral load levels of the experimental group after 1 month,2 months,and 3 months of treatment were (5.25±1.36)×105 copies/mL,(3.36±0.42)×105 copies/mL,(1.04±0.35)×105 copies/mL,lower than the conventional group[(6.33±1.75)×105 copies/mL,(4.15±1.77)×105 copies/mL,(2.24±0.82)×105 copies/mL](P<0.05).After treatment the HA,LN,and PC Ⅲ of the experimental group were 90.25±10.65 ng/mL,75.22±10.36 ng/mL,and 105.35±20.71 ng/mL,lower than the conventional group (95.44±10.28 ng/mL,80.33±10.49 ng/mL,and 120.36±20.57 ng/mL) (P<0.05).After treatment,the TBiL,GPT,and GOT of the experimental group (40.46±10.25 μmol/L,50.25±10.61 U/L,and 51.48±10.37 U/L) were all lower than those in the conventional group (45.61±10.23 μmol/L,55.82±10.31 U/L,56.72±10.24 U/L) (P<0.05).After treatment,the WBC,NE,and LYM of the experimental group were (8.44±1.27)×109/L,(7.65±1.38)×109/L,(3.44±0.52)×109/L,lower than the conventional group[(10.62±2.35)×109/L,(8.77±1.95)×109/L,(4.24±1.79)×109/L](P<0.05).The incidence of poor prognosis in the experimental group was 9.80％ (5/51),lower than that in the conventional group[24.00％ (12/50)](P<0.05).[Conclusion]Polyene phosphatidylcholine can effectively reduce the level of viral load in patients with hepatitis B cirrhosis,which has positive significance in inhibiting the process of liver fibrosis,alleviating liver function damage,alleviating inflammatory reaction and improving the prognosis.
hepatitis Bcirrhosispolyene phosphatidylcholinevirus load levelthe progression of liver fibrosisprognostic situation
万方数据
维普
