Incidence and risk factors of autoimmune encephalitis complicated with blood-brain barrier injury
[Objective]To analyze blood-brain barrier injury and its risk factors in patients with autoimmune encephalitis.[Methods]A total of 90 patients with autoimmune encephalitis confirmed in the hospital were retrospectively analyzed between May 2018 and May 2023.According to presence or absence of blood-brain barrier injury,they were divided into injury group (n=41) and non-injury group (n=49).The clinical data in the two groups were collected.The risk factors of blood-brain barrier injury were analyzed by univariate analysis and logistic multivariate regression analysis.[Results]The incidence of mental abnormality,reaction retardation,EEG δ brush abnormality and skull magnetic resonance abnormality in injury group was higher than that in non-injury group (P<0.05).There were significant differences in the increase of protein level in cerebrospinal fluid,white blood cell (WBC) count,immunoglobulin G (IgG) and 24-hour intramural IgG synthesis rate between the two groups (P<0.05).Logistic regression analysis showed that mental retardation,EEG δ brush abnormality,protein increase>450 mg/L and IgG increase>4 mg/L were independent risk factors of blood-brain barrier injury (P<0.05).[Conclusion]The occurrence of blood-brain barrier injury is related to mental retardation,EEG δ brush abnormality,protein increase>450 mg/L and IgG increase>4 mg/L in patients with autoimmune encephalitis.The therapeutic regimens can be optimized according to the specific conditions of patients with autoimmune encephalitis.
万方数据
维普
