首页|脾动脉栓塞术及修补手术治疗外伤性脾破裂的效果及安全性分析

脾动脉栓塞术及修补手术治疗外伤性脾破裂的效果及安全性分析

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目的 观察脾动脉栓塞术及修补手术治疗外伤性脾破裂的效果及安全性。方法 该研究为前瞻性研究,选择南阳市中心医院2022年1月至2023年6月收治的108例外伤性脾破裂患者为研究对象,依据手术指征不同将其分为修补组(50例)和介入组(58例),修补组实施脾破裂修补术治疗,介入组实施脾动脉介入栓塞治疗,比较两组患者的治疗、恢复情况,血液指标、免疫指标、手术应激指标变化情况,及术后并发症发生情况。结果 在不同治疗方案下,介入组的手术耗时、自体输血量、异体输血量、术后血压回升时间、术后恢复排气时间、住院时间分别为(60。45±10。27)min、(180。33±20。72)mL、(450。36±50。77)mL、(65。77±10。62)min、(20。35±5。72)h、(13。55±3。46)d,均低于修补组[(90。45±20。72)min、(205。36±30。62)mL、(597。45±100。35)mL、(80。44±20。72)min、(25。77±8。45)h、(18。45±5。36)d](P<0。05);介入组术后的血小板计数(PLT)、血红蛋白(Hb)、血清白蛋白(ALB)分别为(120。36±20。73)×109/L、(141。24±20。69)g/L、(45。77±10。36)g/L,均高于修补组[(106。72±20。33)×109/L、(126。44±20。62)g/L、(40。33±10。28)g/L](P<0。05);介入组术后的T淋巴细胞表面抗原CD3+、CD4+分别为(62。44±10。39)%、(37。65±5。41)%,均高于修补组[(57。33±10。41)%、(34。28±5。16)%](P<0。05),CD8+为(25。33±5。16)%,低于修补组[(22。41±5。35)%](P<0。05);介入组术后的去甲肾上腺素(NE)、皮质醇(Cor)分别为(40。27±10。15)μg/L、(273。55±20。74)nmol/L,均低于修补组[(45。69±10。27)μg/L、(288。76±20。42)nmol/L](P<0。05);介入组的术后并发症发生率为8。62%(5/58),低于修补组[24。00%(12/50)](P<0。05)。结论 脾动脉介入栓塞术能有效缩短手术时间,对减少术中输血、促进术后恢复,改善血液指标、免疫功能,并降低手术应激或并发症发生风险均有积极意义。
Effectiveness and safety of splenic artery embolization and repair surgery for traumatic splenic rupture
[Objective]To observe the effectiveness and safety of splenic artery embolization and repair surgery in the treatment for traumatic splenic rupture.[Methods]This study is a prospective study which selected 108 patients with traumatic splenic rupture admitted in Nanyang Central Hospital between January 2022 and June 2023 as the study subjects.They were divided into a repair group (50 cases) and an intervention group (58 cases) based on different surgical indications.The repair group underwent splenic rupture repair surgery,while the intervention group underwent splenic artery embolization therapy.The treatment and recovery status,changes in blood,immune and surgical stress indicators,and the occurrence of postoperative complications of the two groups of patients were compared.[Results]Under different treatment plans,the surgical time,autologous blood transfusion volume,allogeneic blood transfusion volume,postoperative blood pressure recovery time,postoperative recovery exhaust time,and hospitalization time of the intervention group were 60.45±10.27 minutes,180.33±20.72 mL,450.36±50.77 mL,65.77±10.62 minutes,20.35±5.72 hours,and 13.55±3.46 days,lower than the repair group (90.45±20.72 min,205.36±30.62 mL,597.45±100.35 mlL,80.44±20.72 min,25.77±8.45 h,18.45±5.36 d) (P<0.05).After surgery,the PLT,Hb,and ALB of the intervention group were 120.36×109/L±20.73×109/L,141.24±20.69 g/L,45.77±10.36 g/L,higher than the repair group (106.72×109/L±20.33×109/L,126.44±20.62 g/L,40.33±10.28 g/L) (P<0.05).After surgery,the CD3+and CD4+levels in the intervention group were 62.44%±10.39% and 37.65%±5.41%,higher than the repair group (57.33%±10.41% and 34.28%±5.16%) (P<0.05),while CD8+(25.33%±5.16%) was lower than the repair group (22.41%±5.35%) (P<0.05).After surgery,the NE and Cor of the intervention group were 40.27±10.15 μg/L,273.55±20.74 nmol/L,lower than the repair group (45.69±10.27 μg/L,288.76±20.42 nmol/L) (P<0.05).The incidence of postoperative complications in the intervention group was 8.62% (5/58),lower than that in the repair group[24.00% (12/50)](P<0.05).[Conclusion]Splenic artery interventional embolization can effectively shorten the surgical time,reduce intraoperative blood transfusion,promote postoperative recovery,improve blood indicators,immune function,and reduce the risk of surgical stress or complications.

traumatic splenic rupturesplenic artery interventional embolizationsplenic rupture repair surgeryimmune functionsurgical stress

贾雪琳、阎冰

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南阳市中心医院普通外科脾脏外科,河南南阳 473000

外伤性脾破裂 脾动脉介入栓塞术 脾破裂修补术 免疫功能 手术应激

2024

中国医学工程
中国医药生物技术协会 卫生部肝胆肠外科研究中心

中国医学工程

影响因子:0.504
ISSN:1672-2019
年,卷(期):2024.32(12)