The Feasibility of Left Ventricular Myocardial Strain Parameters Derived from Cardiac Magnetic Resonance Feature Tracking(CMR-FT)Technique in Evaluating Immune Checkpoint Inhibitor Associated Myocarditis Patients
Purpose:To explore the feasibility of cardiac magnetic resonance feature tracking(CMR-FT)technique in quantitative assessment of left ventricular myocardial strain in patients with immune checkpoint inhibitor(ICI)associated myocarditis.Methods:A total of 52 subjects(26 patients with ICI associated myocarditis and 26 healthy controls)were included in this study.CMR-FT technique was used to measure basal,mid,apical and global myocardium longitudinal strain(LS),circumferential strain(CS)and radial strain(RS)of left ventricle with CVI42.The SPSS 26.0 software was used to test the differences between the two groups'myocardial strain parameters,while the receiver operating characteristic(ROC)curve analysis was performed to evaluate the clinical diagnostic efficacy of all myocardial strain parameters.Results:LSMid,LSApical,LSGlobal,CSGlobal,CSBasal,CSMid,CSApical were significantly changed in the ICI associated myocarditis group compared with the controls(all P＜0.05).ROC curve analysis showed that LSMid,LSApical,LSGlobal,CSMid,CSApical and CSGlobal could be used for diagnosis of ICI associated myocarditis,while LSGlobal showed the best performance,the area under ROC curve(AUC)was 0.754(cut-off value=-14.22％,sensitivity=0.692,specificity=0.769).Conclusion:Left ventricular myocardial strain parameters derived from CMR-FT had the potential for early detection of left ventricular dysfunction in ICI associated myocarditis patients.
Cardiac magnetic resonanceFeature trackingMyocardial strainImmune checkpoint inhibitor associated myocarditis
万方数据
维普
